The integrated stress response in budding yeast lifespan extension
The ultimate goal of aging research is to develop therapeutic means to extend human lifespan, while reducing susceptibility to many...
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Dec 5, 2017
Bone marrow adipocytes.
Horowitz MC, Berry R, Holtrup B, Sebo Z, Nelson T, Fretz JA, Lindskog D, Kaplan JL, Ables GP, Rodeheffer MS, Rosen CJ. Adipocyte. 2017...
Dec 5, 2017
MR Reduces the Effects of Kidney Injury
Did you know that kidney disease is one of the major causes of early mortality, morbidity, and rising medical costs in the United States?...
Oct 23, 2017
The integrated stress response in budding yeast lifespan extension
Postnikoff SDL, Johnson JE, Tyler JK Microb Cell 2017 Oct;4(11):368-375 PMID: 29167799 Aging is a complex, multi-factorial biological...
Oct 3, 2017
Dietary methionine restriction modulates renal response and attenuates kidney injury in mice
Cooke D, Ouattara A, Ables GP FASEB J. 2017 Oct. PMID: 28970255 Methionine restriction (MR) extends the lifespan across several species,...
Sep 22, 2017
High Fat Diet Improves Healthspan and Memory
A recent study has demonstrated that a ketogenic diet significantly improved memory in aging mice and increased the animal’s chances of...
Sep 22, 2017
High Fat Diet Extends Longevity and Healthspan
As more people age well past their 70s, researchers have increasingly explored the issues of health and quality of life during aging. A...
Aug 18, 2017
Cellular Rejunevation – One Step Closer to Understanding Human Aging
In order to delay aging, the process of aging must first be understood; that the aging of cells is what drives the aging of an organism....
May 30, 2017
Scientifically-designed fasting diet reduces risks for aging diseases
If you could lose weight and reduce your risk of life-threatening disease by dieting five days every few months, would you do it? A...
May 4, 2017
Bone-Derived Hormone Suppresses Food Intake
We often think of bones as immobile structures, but scientists are learning that bones are far more dynamic than once believed. Research...
Apr 12, 2017
Preliminary Findings on the Effects of Rapamycin on Cardiac Health of Companion Dogs
Recent advances in geroscience have begun to explain the molecular mechanisms that link aging with disease, making age the greatest risk...
Apr 4, 2017
In Review: The Many Effects of Methionine Restriction
Our work at the Orentreich Foundation for the Advancement of Science has proven that methionine restriction (MR) extends lifespan and has...
Feb 7, 2017
NYAS eBriefing now available for Aging and Nutrition: Novel Approaches and Techniques
The New York Academy of Sciences recently announced that the multimedia eBriefing of the symposium, Aging and Nutrition: Novel Approaches...
Jan 25, 2017
2016 OFAS Report of Directors
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Jan 25, 2017
Improving Lifespan and Healthspan in a Disorder Causing Early Aging
A team of researchers lead by Drs. Evandro Fang and Vilhelm Bohr of the National Institute of Aging–National Institutes of Health have...
Jan 17, 2017
Pleiotropic responses to methionine restriction
Ables GP, Johnson JE Exp. Gerontol. 2017 Jan; PMID: 28108330 Methionine restriction (MR) extends lifespan across different species. The...
Jan 13, 2017
Preserving DNA Methylation During Aging
One of the negative aspects of aging is the decreased ability to maintain normal cellular functions, which eventually manifests as...
Jan 3, 2017
Short term methionine restriction increases hepatic global DNA methylation in adult but not young ma
Mattocks DA, Mentch SJ, Shneyder J, Ables GP, Sun D, Richie JP Jr, Locasale JW, Nichenametla SN Exp Gerontol. 2017 Feb; PMID: 27940170 ...
Dec 22, 2016
NYAS Symposium – Aging & Nutrition: Novel Approaches & Techniques
OFAS and The Sackler Institute for Nutrition Science at The New York Academy of Sciences (NYAS) joined together to present a conference...
Nov 30, 2016
Naturally occurring p16Ink4a-positive cells shorten healthy lifespan
Cellular senescence, a stress-induced state in which cells are unable to divide, is known to prevent the proliferation of potentially...
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