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Welcome to your source for news on lifespan and aging research.

Oct 1, 2021

Webinar for Aging Science Talks Chaired by Dr. Nichenametla

OFAS Associate Scientist Dr. Sailendra Nichenametla will chair a webinar, “Sulfur Amino Acid Restriction – Moving from Animals to...

Dec 5, 2017

Healthspan

MR Reduces the Effects of Kidney Injury

Did you know that kidney disease is one of the major causes of early mortality, morbidity, and rising medical costs in the United States?...

Oct 3, 2017

Publications

Dietary methionine restriction modulates renal response and attenuates kidney injury in mice

Cooke D, Ouattara A, Ables GP FASEB J. 2017 Oct. PMID: 28970255 Methionine restriction (MR) extends the lifespan across several species,...

In Review: The Many Effects of Methionine Restriction

Apr 4, 2017

Healthspan

In Review: The Many Effects of Methionine Restriction

Our work at the Orentreich Foundation for the Advancement of Science has proven that methionine restriction (MR) extends lifespan and has...

Jan 3, 2017

Publications

Short term methionine restriction increases hepatic global DNA methylation in adult but not young ma

Mattocks DA, Mentch SJ, Shneyder J, Ables GP, Sun D, Richie JP Jr, Locasale JW, Nichenametla SN Exp Gerontol. 2017 Feb; PMID: 27940170 ...

Methionine-restricted diet inhibits growth of MCF10AT1-derived mammary tumors by increasing cell cyc

Jul 22, 2016

Healthspan

Methionine-restricted diet inhibits growth of MCF10AT1-derived mammary tumors by increasing cell cyc

Past research has shown that dietary methionine restriction (MR) improves healthspan in part by reducing fat and increasing insulin...

May 17, 2016

Publications

Methionine-restricted diet increases miRNAs that can target RUNX2 expression and alters bone structu

Plummer J, Park M, Perodin F, Horowitz MC, Hens JR J. Cell. Biochem. 2016 May; PMID: 27191548 Dietary methionine restriction (MR)...

Dec 31, 2015

Publications

Methionine-restricted diet inhibits growth of MCF10AT1-derived mammary tumors by increasing cell cyc

Hens JR, Sinha I, Perodin F, Cooper T, Sinha R, Plummer J, Perrone CE, Orentreich D BMC Cancer 2016;16(1):349 PMID: 27255182 BACKGROUND:...

Oct 31, 2015

Publications

Histone methylation dynamics and gene regulation occur through the sensing of one-carbon metabolism

Mentch SJ, Mehrmohamadi M, Huang L, Liu X, Gupta D, Mattocks D, Gόmez Padilla P, Ables G, Bamman MM, Thalacker-Mercer AE, Nichenametla...

Dec 31, 2010

Publications

Cysteine supplementation reverses methionine restriction effects on rat adiposity: significance of s

Elshorbagy AK, Valdivia-Garcia M, Mattocks DA, Plummer JD, Smith AD, Drevon CA, Refsum H, Perrone CE J. Lipid Res. 2011 Jan;52(1):104-12...

Oct 31, 2010

Publications

Sulfur amino acids in methionine-restricted rats: hyperhomocysteinemia

Elshorbagy AK, Valdivia-Garcia M, Refsum H, Smith AD, Mattocks DA, Perrone CE Nutrition 2010 Nov-Dec;26(11-12):1201-4 PMID: 20080389 ...

Jun 30, 2010

Publications

Methionine restriction effects on mitochondrial biogenesis and aerobic capacity in white adipose tis

Perrone CE, Mattocks DA, Jarvis-Morar M, Plummer JD, Orentreich N Metab. Clin. Exp. 2010 Jul;59(7):1000-11 PMID: 20045141 Methionine...

Dec 31, 2007

Publications

Methionine restriction effects on 11β-HSD1 activity and lipogenic/lipolytic balance in F344 rat adip

Perrone CE, Mattocks DA, Hristopoulos G, Plummer JD, Krajcik RA, Orentreich N J. Lipid Res. 2008 Jan;49(1):12-23 PMID: 17909224 ...

Jul 31, 2006

Publications

Methionine restriction decreases visceral fat mass and preserves insulin action in aging male Fische

Malloy VL, Krajcik RA, Bailey SJ, Hristopoulos G, Plummer JD, Orentreich N Aging Cell 2006 Aug;5(4):305-14 PMID: 16800846 Reduced dietary...

Aug 31, 2004

Publications

Tissue glutathione and cysteine levels in methionine-restricted rats

Richie JP, Komninou D, Leutzinger Y, Kleinman W, Orentreich N, Malloy V, Zimmerman JA Nutrition 2004 Sep;20(9):800-5 PMID: 15325691...

Apr 1, 2004

Publications

Methionine restriction inhibits age-related spontaneous tumorigenesis in F344 rats.

Aging is the strongest risk factor for most forms of cancer, however, little is known regarding the mechanisms involved. Dietary...

Nov 30, 1994

Publications

Methionine restriction increases blood glutathione and longevity in F344 rats

Richie JP, Leutzinger Y, Parthasarathy S, Malloy V, Orentreich N, Zimmerman JA FASEB J. 1994 Dec;8(15):1302-7 PMID: 8001743 Little is...

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