Jay E. Johnson, Ph.D.
Associate Scientist
Education
Research Associate, University of Pennsylvania
Postdoctoral Fellowship, University of Pennsylvania
Postdoctoral Fellowship Fox Chase Cancer Center & Memorial Health University Medical Center
Ph.D., Molecular Biology Case Western Reserve University School of Medicine
Research Rotations Case Western Reserve University
B.S., Biotechnology Rochester Institute of Technology
About Dr. Johnson
Dr. Johnson received his doctorate in Molecular Biology from Case Western Reserve University (Cleveland, OH). His post-doctoral work at Fox Chase Cancer Center (Philadelphia, PA) used a liposarcoma model system to investigate the maintenance of telomeres, important nucleoprotein structures with roles in aging and cancer. Dr. Johnson then joined the University of Pennsylvania (Philadelphia), where his early work explored cellular defects in patients with Werner and Bloom’s syndromes, genetic diseases characterized by accelerated aging and cancer predisposition. Dr. Johnson’s recent work has focused on exploring the mechanistic basis of the benefits of methionine restriction in S. cerevisiae and cultured mouse and human cells.
Current Research
The dual aims of Dr. Johnson’s research are characterizing the cellular mechanisms underlying the benefits of methionine restriction (MR), and identification of novel MR-interventions that improve healthspan. Because many of the mechanisms that regulate mammalian longevity were first identified as mechanisms that promote longevity in yeast, Dr. Johnson’s group uses yeast models as well as mammalian cells and laboratory mice in his multifaceted approach.
